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Pig heart transplant: how long can you live after procedure - as US man dies after months xenotransplant

A xenotransplant had been the subject of Malorie Blackman’s book Pig Heart Boy

<p>After the procedure, doctors have said that the patient, David Bennett, had been doing well (Photo: University of Maryland Medical Centre)</p>

After the procedure, doctors have said that the patient, David Bennett, had been doing well (Photo: University of Maryland Medical Centre)

In a medical first, doctors in the USA transplanted a genetically modified pig heart into a human patient in an effort to save his life.

While the surgery was initially a success, it has now been announced that patient David Bennett has passed away.

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But what happened to the patient, and how did the procedure go?

This is everything you need to know.

What happened in the US?

At the University of Maryland Medical Centre (UMMC), a first of its kind transplant was successfully carried out wherein a 57-year-old man with terminal heart disease received a transplant of a genetically modified pig heart.

Mr Bennett had been deemed ineligible for a conventional heart transplant, leaving the experimental surgery as his only option. In addition to not qualifying to be put on the transplant list, he was also deemed ineligible for an artificial heart pump due to his arrhythmia.

The day before the surgery, Mr Bennett said: “It was either die or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice.”

On New Year’s Eve, the US Food and Drug Administration (FDA) granted emergency authorisation for the surgery through its “expanded access (compassionate use) provision”.

The surgery is a medical first of its kind (Photo: University of Maryland Medical Centre)

These are granted when an experimental procedure is the only option left for a patient facing a serious or life threatening medical condition. The UMMC says that this authorisation is given “in the hope of saving the patient’s life”.

Bartley P Griffith, who surgically transplanted the pig heart into Mr Bennett, said: “This was a breakthrough surgery and brings us one step closer to solving the organ shortage crisis.

“There are simply not enough donor human hearts available to meet the long list of potential recipients.

“We are proceeding cautiously, but we are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future.”

When did David Bennett die?

On 9 March 2022, it was announced that Mr Bennett had passed away two months after his surgery.

The surgery had initially been deemed a success, and Mr Bennett lived relatively healthily for the eight weeks.

However, his condition began to rapidly deteriorate before he passed away on 8 March.

Dr Griffith said: “He proved to be a brave and noble patient who fought all the way to the end.”

It has also been noted that while Mr Bennett did pass away after the procedure, he was not in good health before the transplant.

Mr Bennett’s son, David Jnr, said: “We are grateful for every innovative moment, every crazy dream, every sleepless night that went into this historic effort.”

What is xenotransplantation?

Xenotransplantation refers to a procedure wherein a human is given a transplant/implant/infusion from a nonhuman animal source.

The FDA explains that a xenotransplantation is “any procedure that involves the transplantation, implantation or infusion into a human recipient of either (a) live cells, tissues, or organs from a nonhuman animal source, or (b) human body fluids, cells, tissues or organs that have had ex vivo contact with live nonhuman animal cells, tissues or organs”.

It adds that the development of xenotransplantation has been, in part, driven by the fact that the demand for human organs for clinical transplantation “far exceeds the supply”.

The pig heart underwent a total of 10 gene edits to ensure that it would not be rejected (Photo: University of Maryland Medical Centre)

The UMMC said that the donor pig heart underwent a number of gene edits to ensure that it would not be rejected by Mr Bennett.

According to the UMMC, “three genes - responsible for rapid antibody-mediated rejection of pig organs by humans - were “knocked out” in the donor pig”. Six human genes that are responsible for the immune acceptance of the pig heart were then “inserted into the genome”.

“Lastly, one additional gene in the pig was knocked out to prevent excessive growth of the pig heart tissue, which totaled 10 unique gene edits made in the donor pig,” the UMMC said.

What are the risks of xenotransplantation?

The FDA says: “Although the potential benefits are considerable, the use of xenotransplantation raises concerns regarding the potential infection of recipients with both recognized and unrecognized infectious agents and the possible subsequent transmission to their close contacts and into the general human population.

The procedure is still highly experimental (Photo: University of Maryland Medical Centre)

“Of public health concern is the potential for cross-species infection by retroviruses, which may be latent and lead to disease years after infection.

“Moreover, new infectious agents may not be readily identifiable with current techniques.”

Mr Bennett had been fully informed of the procedure’s risks, and was informed that the procedure was experimental with unknown potential risks and benefits.

Has xenotransplantation been attempted in the past?

Back in the 1980s, xenotransplants were tried for the first time - however, following a surgery with Stephanie Fae Beauclair, they were largely abandoned.

Stephanie Fae Beauclair, known as Baby Fae, was born on 14 October 1984 with hypoplastic left heart syndrome.

The story of Baby Fae was the subject of the documentary Stephanie’s Heart: The Story of Baby Fae (Photo: Stephanie’s Heart: The Story of Baby Fae)

On 26 October, days after her birth, Baby Fae became the first infant to be subjected to a xenotransplant procedure, as doctors used a baboon heart to replace her own failing heart.

Within a month of the procedure, Baby Fae died - but in her short life, she had, at the time, become the longest living recipient of a non-human heart.

However, since then, pig heart valves have successfully been used for replacing valves in humans for many years.

Is Pig Heart Boy book a true story?

Pig Heart Boy is a children’s book that was written by Malorie Blackman, and was first published in 1997.

The book tells the story of Cameron, a 13-year-old boy who is in need of a heart transplant when he is offered a highly experimental and controversial surgery in which he would be given a pig’s heart.

Pig Heart Boy is not based on a true story, and is simply a fictional story.

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