It will be the first FMQs in eight years not to be led by Nicola Sturgeon – and if the SNP leadership campaign was anything to go by, along with comments made by Opposition leaders, then we could be set for fireworks.
What can we expect from FMQs?
The new First Minister will be quizzed by MSPs including Scottish Conservative leader Douglas Ross and Scottish Labour's Anas Sarwar.
Mr Ross will ask four questions, before Mr Sarwar puts three to the first minister.
Last month in a fiery session of First Minister’s Questions, Nicola Sturgeon was forced to defend the record of Mr Yousaf multiple times, with the Scottish Conservatives stating he should have been “sacked, not promoted”.
If attacks from Labour and the Conservatives are anything to go by in the past, then significant health care questions could be on the agenda.
We can also expect new faces on the front rows in the Scottish Parliament after Humza Yousaf unveiled his new cabinet.
When is FMQs?
First Minister’s Questions will be held at 12 noon today
How to watch FMQs?
The weekly session of the Scottish Parliament will be live streamed on Scottish Parliament TV