Taking place in Barbados, all five matches will be played across a nine-day period from January 22 to January 30.
The West Indies will then welcome England back for a three-match Test series to compete for the Richards-Botham Trophy in March.
West Indies vs England, T20I series dates
Saturday, January 22 - first T20I West Indies vs England
Sunday, January 23 - second T20I West Indies vs England
Wednesday, January 26 - third T20I West Indies vs England
Saturday, January 29 - fourth T20I West Indies vs England
Sunday, January 30 - fifth T20I West Indies vs England
West Indies vs England, Test series dates
March 1-4 - Four-day warm-up match at Coolidge Cricket Ground, Antigua
March 8-12 - first Test match, West Indies vs England, at Sir Vivian Richards Cricket Ground, Antigua
March 16-20 - second test match, West Indies vs England, at Kensington Oval, Barbados
March 24-28 - third Test match, West Indies vs England, at National Cricket Stadium, Grenada
What time does it start?
The T20I series gets underway with the first match at 4pm (8pm BST) on Sunday January 22.
Each match will take place at the same time each day (4pm) up until the final match of the series on Sunday January 30.
The Test series will then kick off on Tuesday March 8 until Saturday March 12, beginning at 10am.
Eoin Morgan will lead out a squad full of new faces this weekend, with no players involved in the Ashes named.
This means England will be without the likes of Ben Stokes, Jos Buttler, Jonny Bairstow and Mark Wood.
Uncapped seamers George Garton and David Payne have been included, with Phil Salt, Tom Banton and Saqib Mahmood also featuring.
Squad: Eoin Morgan (captain), Moeen Ali, Tom Banton, Sam Billings, Liam Dawson, George Garton, Chris Jordan, Liam Livingstone, Saqib Mahmood, Tymal Mills, David Payne, Adil Rashid, Jason Roy, Phil Salt, Reece Topley, James Vince.
West Indies will see Kieron Pollard return as captain, while Chris Gayle, Evin Lewis and Anderson Phillip are absent from the squad.
Squad: Kieron Pollard (captain), Nicholas Pooran, Fabian Allen, Darren Bravo, Roston Chase, Sheldon Cottrell, Dominic Drakes, Shai Hope, Akeal Hosein, Jason Holder, Brandon King, Kyle Mayers, Rovman Powell, Romario Shepherd, Odean Smith, Hayden Walsh Jr