They go into these mouthwatering clashes in very different places following the meeting between the sides at the weekend.
Celtic waltzed to a 4-0 home success over their rivals in a convincing manner, opening up a five-point lead at the top of the Scottish Premiership.
That, alongside the difficulty of the respective Champions League groups they are in, is reflected in the bookmakers’ price of which of the Glasgow giants will pick up more points across their six European fixtures.
As well as Real Madrid, Celtic have RB Leipzig and Shakhtar Donetsk, while Liverpool and Napoli make up Rangers’ group.
Celtic are seen as 1/ 2 favourites to pick up the most points with BetVictor, while Rangers are priced at 9/4. The same total is 6/1.