The lock forward has been selected to make his 149th international appearance.
It will be his 140th game for Wales and he has also won nine caps for the British & Irish Lions.
Jones captains a side showing six changes from that beaten by France in a Paris friendly last weekend.
Cardiff Blues flanker Shane Lewis-Hughes makes his debut, with Will Rowlands and Tomas Francis also coming into the pack.
Gareth Davies replaces Rhys Webb at scrum-half, Owen Watkin comes into the centre and Liam Williams returns in the back three at the expense of George North.
Wales are trying to stop a losing run which extended to four games with the defeat in Paris.
Scotland, by contrast, are seeking a fourth consecutive win. However, the Scots have not win in Wales since 2002.